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Nutr J. 2019 Jan 23;18(1):6. doi: 10.1186/s12937-019-0432-8.

Effect of maternal pre-pregnancy BMI and weekly gestational weight gain on the development of infants.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
2
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.
3
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. yh.paper_xjtu@aliyun.com.
4
Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Xi'an, China. yh.paper_xjtu@aliyun.com.
5
Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, China. yh.paper_xjtu@aliyun.com.
6
School of Public Health, Xi'an Jiaotong University Health Science Center, No. 76 West Yanta Road, PO Box 46, Xi'an, Xi'an, 710061, Shaanxi, China. yh.paper_xjtu@aliyun.com.

Abstract

OBJECTIVE:

The aim of the present study is to identify the average effect across different time points and to specify the time effects of maternal pre-pregnancy BMI and weekly gestational weight gain on the mental development and physical growth of infants.

METHODS:

The present cohort study used a repeated measures study design that began in 2004 with follow up at 3, 6, 12, 18, and 24 months of age. The participants were a subset from a controlled, cluster-randomized, double-blind trial. Bayley Scales of Infant Development (BSID) were used to estimate the mental development of infants. A generalized estimating equation linear model was used to estimate the effects of maternal BMI and weight gain.

RESULTS:

The average effect of maternal BMI and weight gain on the weight for age Z scores (WAZ), length for age Z scores (LAZ) and mental development index (MDI) across the different time points of infants was significant. In addition, the maternal BMI and weight gain were positively and significantly associated with the WAZ and LAZ in infants of different ages. However, the effect of weekly gestational weight gain was significant only during the earlier period of life (3 months, Coefficient: 11.15, 95%CI: 4.89-17.41).

CONCLUSIONS:

Our results indicate positive effects of pre-pregnancy and prenatal nutrition on the physical growth of infants. Weekly gestational weight gain of the pregnant women had a positive effect on the mental development of the infants, but this effect appears to decline over time.

KEYWORDS:

Development of infants; Maternal pre-pregnancy BMI; Weekly gestational weight gain

PMID:
30674315
PMCID:
PMC6345052
DOI:
10.1186/s12937-019-0432-8
[Indexed for MEDLINE]
Free PMC Article

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