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Kidney Int. 2019 Feb;95(2):254-256. doi: 10.1016/j.kint.2018.10.011.

The renal draining lymph nodes in acute inflammatory kidney disease.

Author information

1
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Pediatric Nephrology, Monash Health, Clayton, Victoria, Australia. Electronic address: richard.kitching@monash.edu.
2
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Clinical Immunology, Monash Health, Clayton, Victoria, Australia.

Abstract

Renal lymphatics are implicated in renal disease, but their function in inflammatory kidney diseases is relatively poorly defined. In the current issue, Kasinath et al. examine the role of the kidney draining lymph node in experimental glomerulonephritis, as well the role of fibroblastic reticular cells within lymph nodes. Removing the kidney-draining lymph nodes prior to the induction of glomerulonephritis attenuated disease, as did interventions that affected the function of lymph nodes in general.

PMID:
30665562
DOI:
10.1016/j.kint.2018.10.011

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