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Sci Transl Med. 2019 Jan 9;11(474). pii: eaau1458. doi: 10.1126/scitranslmed.aau1458.

Challenges and strategies for developing efficacious and long-lasting malaria vaccines.

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Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.
Central Clinical School and Department of Microbiology, Monash University, Melbourne, Victoria 3004, Australia.
Department of Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.
Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.
ISGlobal, Hospital Clínic - Universitat de Barcelona, Carrer Rosselló 153 (CEK building), E-08036 Barcelona, Catalonia, Spain.
Institute for Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.
Menzies School of Health Research, Darwin, Northern Territory 0810, Australia.


Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly efficacious and durable vaccines against Plasmodium falciparum and Plasmodium vivax malaria. Greater knowledge of mechanisms and key targets of immunity are needed to accomplish this goal, together with new strategies for generating potent, long-lasting, functional immunity against multiple antigens. Implementation considerations in endemic areas will ultimately affect vaccine effectiveness, so innovations to simplify and enhance delivery are also needed. Whereas challenges remain, recent exciting progress and emerging knowledge promise hope for the future of malaria vaccines.

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