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Nutrients. 2019 Jan 5;11(1). pii: E101. doi: 10.3390/nu11010101.

Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Author information

1
Department of Nutritional Science and Food Management, Ewha Womans Universiy, Seoul 03760, Korea. nutrishee@gmail.com.
2
Department of Nutritional Science and Food Management, Ewha Womans Universiy, Seoul 03760, Korea. ynlim@ewha.ac.kr.
3
Department of Nutritional Science and Food Management, Ewha Womans Universiy, Seoul 03760, Korea. eugenekim@ewha.ac.kr.
4
Department of Systems Biotechnology, Konkuk University, Seoul 05029, Korea. jes708@konkuk.ac.kr.
5
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea. sdh14031988@naver.com.
6
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea. chlee123@konkuk.ac.kr.
7
Department of Food and Nutrition, Hannam University, Daejeon 34430, Korea. eunmi_park@hnu.kr.
8
Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. jina.hong@amway.com.
9
Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. rod.velliquette@amway.com.
10
Department of Nutritional Science and Food Management, Ewha Womans Universiy, Seoul 03760, Korea. orank@ewha.ac.kr.
11
Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Korea. jiyeonk@seoultech.ac.kr.

Abstract

Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites.

KEYWORDS:

DNA damage; ROS scavenging; antioxidant capacity; human clinical study; phytonutrients

PMID:
30621298
PMCID:
PMC6356358
DOI:
10.3390/nu11010101
[Indexed for MEDLINE]
Free PMC Article

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