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Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02530-18. doi: 10.1128/AAC.02530-18. Print 2019 Mar.

High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness.

Author information

1
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
2
Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
3
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran f_vaziri@pasteur.ac.ir.

Abstract

In the regions where bedaquiline (BDQ) is introduced into the regimen, analysis of MIC and screening for preexisting resistance mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome. It was also concluded that efflux pumps play a pivotal role in intrinsic BDQ resistance; therefore, the potential of verapamil as an adjunctive therapy to combat BDQ resistance should be investigated.

KEYWORDS:

MIC; WGS; bedaquiline; efflux pumps; verapamil

PMID:
30602521
DOI:
10.1128/AAC.02530-18

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