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J Nat Prod. 2019 Jan 2. doi: 10.1021/acs.jnatprod.8b00871. [Epub ahead of print]

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities.

Author information

1
Molecular Targets Program, Center of Cancer Research , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.
2
Basic Science Program, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute , Frederick , Maryland 21702-1201 , United States.
3
Lymphoid Malignancies Branch, Center for Cancer Research , National Cancer Institute , Bethesda , Maryland 20892 , United States.
4
Natural Products Discovery Group, Department of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019-5251 , United States.
5
Mycology Unit , Universitat Rovira i Virgili , C/Sant Llorenç 21 , 43201 Reus , Spain.
6
Illinois Natural History Survey , University of Illinois , 1816 South Oak Street , Champaign , Illinois 61820-6970 , United States.
7
Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis , National Cancer Institute , Frederick , Maryland 21701-1201 , United States.

Abstract

Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 7-11. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.

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