Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura

Ann Neurol. 2019 Feb;85(2):284-290. doi: 10.1002/ana.25407. Epub 2019 Jan 17.

Abstract

Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Ann Neurol 2019; 1-7 ANN NEUROL 2019;85:284-290.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Amyloid beta-Peptides / metabolism*
  • Cadaver
  • Cancer Survivors
  • Cerebral Amyloid Angiopathy / diagnostic imaging*
  • Cerebral Amyloid Angiopathy / metabolism
  • Cerebral Amyloid Angiopathy / pathology
  • Cerebral Amyloid Angiopathy / physiopathology
  • Craniotomy
  • Dura Mater / metabolism
  • Dura Mater / transplantation*
  • Embolization, Therapeutic
  • Female
  • Hemangioma, Cavernous, Central Nervous System / therapy
  • Humans
  • Iatrogenic Disease
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Papilloma, Choroid Plexus / surgery
  • Parotid Neoplasms / therapy
  • Skull Fractures / surgery

Substances

  • Amyloid beta-Peptides