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Gen Psychiatr. 2018 Nov 10;31(3):e100017. doi: 10.1136/gpsych-2018-100017. eCollection 2018.

CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) presenting as psychosis.

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Department of Psychiatry, Shyam Shah Medical College Rewa, Rewa, Madhya Pradesh, India.
Masik Aarogyashala Gwalior, Indore, Madhya Pradesh, India.
Department of Psychiatry, M. G. M. Medical College Indore, Indore, Madhya Pradesh, India.


Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is the most common monogenic form of cerebral small-vessel disease characterised by recurrent strokes. Behavioural disturbance also presents in a significant proportion of subjects as neurotic spectrum disorders and psychotic features are rarely reported. In this case report, we highlight a 32-year-old man with CADASIL syndrome, who had overt psychotic symptoms with neurological signs later on.


CADASIL; genetic strokes; psychosis; syndrome

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