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Mov Disord. 2019 Feb;34(2):281-285. doi: 10.1002/mds.27591. Epub 2018 Dec 21.

Statin use and delayed onset of Huntington's disease.

Author information

1
Department of Psychiatry, Carver College of Medicine at the University of Iowa, Iowa City, Iowa, USA.
2
Department of Pharmaceutical Care, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
3
Department of Pharmacy Practice and Science, The University of Iowa College of Pharmacy, Iowa City, Iowa, USA.
4
Department of Neurology, Carver College of Medicine at the University of Iowa, Iowa City, Iowa, USA.
5
Stead Family Department of Pediatrics at the University of Iowa, Iowa City, Iowa, USA.
6
The Veteran's Affair Medical Center of Iowa City, Iowa City, Iowa, USA.

Abstract

BACKGROUND:

There is evidence to suggest that 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) may be beneficial in Huntington's disease (HD).

OBJECTIVE:

This study aimed to determine if statin use was associated with delayed motor diagnosis in participants with premotor HD.

METHODS:

Among premotor HD participants from the Enroll-HD database, statin users were propensity score matched with statin nonusers based on cytosine-adenine-guanine-age product score, cytosine-adenine-guanine repeat length, baseline age, sex, and region. A Cox regression survival analysis compared the annualized hazard ratio (HR) of receiving a motor diagnosis between the 2 groups.

RESULTS:

The annualized HR of progressing to an HD motor diagnosis was lower in the statin users (n = 89) when compared with the statin nonusers (n = 89; HR = 0.27 [95% CI 0.18-0.50], P < .0001).

CONCLUSIONS:

In patients with premotor HD, statin use was associated with a delayed motor diagnosis of HD. Further studies are warranted to investigate if statins would be an effective disease-modifying therapy for HD. © 2018 International Parkinson and Movement Disorder Society.

PMID:
30576007
DOI:
10.1002/mds.27591

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