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BMJ. 2018 Dec 18;363:k5130. doi: 10.1136/bmj.k5130.

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline.

Author information

1
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
2
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
3
Department of Medicine, University of Toronto, Toronto, Canada.
4
The Centre of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
5
Department of Medicine, McMaster University, Hamilton, Canada.
6
Deparment of Medicine, NUI Galway, Galway, Ireland.
7
Department of Medicine, Innlandet Hospital Trust-division, Gjøvik, Norway.
8
Division of General Internal Medicine & Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland.
9
Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
10
Department of Neurology, Kasturba Medical College, Manipal, India.
11
Division of Neurology, Stroke Centre, University Hospitals of Geneva, Geneva, Switzerland.
12
Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
13
Stroke Foundation of Australia.
14
School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
15
School of Nursing, Midwifery and Paramedicine, University of Sunshine Coast, Maroochydore, Australia.
16
Peter Lougheed Hospital, Calgary, Canada.
17
Cochrane Consumers Group.
18
Department of Surgery, Stanford University, Stanford, California.
19
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada rochwerg@mcmaster.ca.

Abstract

WHAT IS THE ROLE OF DUAL ANTIPLATELET THERAPY AFTER HIGH RISK TRANSIENT ISCHAEMIC ATTACK OR MINOR STROKE? SPECIFICALLY, DOES DUAL ANTIPLATELET THERAPY WITH A COMBINATION OF ASPIRIN AND CLOPIDOGREL LEAD TO A GREATER REDUCTION IN RECURRENT STROKE AND DEATH OVER THE USE OF ASPIRIN ALONE WHEN GIVEN IN THE FIRST 24 HOURS AFTER A HIGH RISK TRANSIENT ISCHAEMIC ATTACK OR MINOR ISCHAEMIC STROKE? AN EXPERT PANEL PRODUCED A STRONG RECOMMENDATION FOR INITIATING DUAL ANTIPLATELET THERAPY WITHIN 24 HOURS OF THE ONSET OF SYMPTOMS, AND FOR CONTINUING IT FOR 10-21 DAYS CURRENT PRACTICE IS TYPICALLY TO USE A SINGLE DRUG.

PMID:
30563885
DOI:
10.1136/bmj.k5130

Conflict of interest statement

Competing interests: All authors have completed the BMJ Rapid Recommendations interests disclosure form, and a description of all disclosures is reported in appendix 1 on bmj.com. As with all BMJ Rapid Recommendations, the executive team and The BMJ judged that no panel member had any financial conflict of interest. Professional and academic interests are minimised as much as possible, while maintaining necessary expertise on the panel to make fully informed decisions.

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