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J Cardiol Cases. 2014 Jun 6;10(2):54-57. doi: 10.1016/j.jccase.2014.04.009. eCollection 2014 Aug.

Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis.

Author information

1
Department of Cardiovascular Medicine, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan.
2
Takamatsu Municipal Hospital, Takamatsu, Kagawa, Japan.
3
Department of Medical Education, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan.
4
Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan.
5
Anan Kyoei Hospital, Anan, Tokushima, Japan.

Abstract

Rates of morbidity and mortality from cardiovascular disease are high in patients with rheumatoid arthritis (RA); however, the mechanisms and biomarkers that reflect coronary plaque vulnerability have not yet been established. We present a case of acute coronary syndrome (ACS) presumably caused by exacerbation of chronic inflammation of RA, in which an abrupt increase in serum triglyceride was seen on the day of onset of ACS but not during effort angina. This case suggests that RA patients with an abrupt increase in triglyceride need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture. <Learning objective: Triglyceride might be a sensitive biomarker of activated macrophages and plaque vulnerability in patients with RA. RA patients with an abrupt increase in triglyceride might need intensive care including anti-platelet and statin therapy for the prevention of coronary plaque rupture.>.

KEYWORDS:

Acute coronary syndrome; Biomarker; Triglyceride; Tumor necrosis factor-α

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