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Immunol Cell Biol. 2018 Dec 9. doi: 10.1111/imcb.12222. [Epub ahead of print]

Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development.

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Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Department of Medicine, Monash University, Clayton, VIC, Australia.
Department of Physiology, Monash University, Clayton, VIC, Australia.
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Liver Immunology program Centenary Institute, AW Morrow Gastroenterology and Liver Centre and Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW, Australia.


Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule that is overexpressed in the liver but its immunological function is not known. We have previously shown that H2-Q10 is a ligand for the natural killer cell receptor Ly49C and now, using H2-Q10-deficient mice, we demonstrate that H2-Q10 can also stabilize the expression of Qa-1b. In the absence of H2-Q10, the development and maturation of conventional hepatic natural killer cells is disrupted. We also provide evidence that H2-Q10 is a new high affinity ligand for CD8αα and controls the development of liver-resident CD8αα γδT cells. These data demonstrate that H2-Q10 has multiple roles in the development of immune subsets and identify an overlap of recognition within the class Ib MHC that is likely to be relevant to the regulation of immunity.


CD8αα; natural killer cells; non-classical MHC; γδT cells


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