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RNA Biol. 2019 Jan;16(1):1-4. doi: 10.1080/15476286.2018.1557498. Epub 2018 Dec 17.

The nuclear export of circular RNAs is primarily defined by their length.

Author information

1
a School of Life Sciences , Chongqing University , Chongqing , China.
2
b Institute of Advanced Interdisciplinary Studies , Chongqing University , Chongqing , China.
3
c Department of Biochemistry and Biophysics , University of Pennsylvania, Perelman School of Medicine , Philadelphia , PA , USA.

Abstract

Although it was long assumed that eukaryotic pre-mRNAs are almost always spliced to generate linear mRNAs, it is now clear that thousands of protein-coding genes can be non-canonically spliced using backsplicing to produce circular RNAs (circRNAs). Most mature circRNAs accumulate in the cytoplasm; however, little is known about how circRNAs are exported from the nucleus to the cytoplasm as they lack many of the common signals used for mRNA export. In this point-of-view article, we will discuss our recently identified circRNA nuclear export pathway and address important open questions in the field.

KEYWORDS:

Hel25E; UAP56; URH49; biogenesis; circRNA; function; nuclear export

PMID:
30526278
PMCID:
PMC6380329
[Available on 2019-12-17]
DOI:
10.1080/15476286.2018.1557498
[Indexed for MEDLINE]

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