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J Clin Res Pediatr Endocrinol. 2019 Sep 3;11(3):311-318. doi: 10.4274/jcrpe.galenos.2018.2018.0204. Epub 2018 Dec 11.

Magnesium and Anti-phosphate Treatment with Bisphosphonates for Generalised Arterial Calcification of Infancy: A Case Report

Author information

1
Ümraniye Training and Research Hospital, Clinic of Pediatric Endocrinology, İstanbul, Turkey
2
Ümraniye Training and Research Hospital, Clinic of Radiology, İstanbul, Turkey
3
Ümraniye Training and Research Hospital, Clinic of Pediatric Nephrology, İstanbul, Turkey
4
Ümraniye Training and Research Hospital, Clinic of Pediatric Rheumatology, İstanbul, Turkey

Abstract

Generalized arterial calcification of infancy (GACI) is a rare autosomal-recessive disorder, characterized by calcification of the internal elastic lamina, fibrotic myointimal proliferation of muscular arteries and resultant arterial stenosis. Treatment with bisphosphonates has been proposed as a means of reducing arterial calcifications in GACI patients, although there is no formalized treatment approach. The case reported here was a patient with severe GACI diagnosed at three months of age who had no response to bisphosphonate treatment, but clinically improved after the initiation of magnesium and anti-phosphate (using calcium carbonate) treatments. In patients unresponsive to bisphosphonate, magnesium and anti-phosphate treatment may be attempted.

KEYWORDS:

Generalized arterial calcification; infant; treatment; magnesium; etidronate

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