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Pharm Dev Technol. 2018 Dec 5:1-25. doi: 10.1080/10837450.2018.1556689. [Epub ahead of print]

In Vivo Study of mPEG-PCL as a Nanocarriers for Anti-Inflammatory Drug Delivery of Simvastatin.

Author information

1
a Student research committee, Zanjan University of medical sciences , Iran .
2
b Department of Pharmaceutical Biomaterials, School of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran .
3
c School of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran .
4
d Zanjan Applied Pharmacology Research Center , Zanjan University of Medical Sciences , Zanjan , Iran .
5
e Cancer Gene Therapy Research Center , Zanjan University of Medical Sciences , Zanjan , Iran .
6
f Zanjan Pharmaceutical Nanotechnology Research Center , Zanjan University of Medical Sciences , Zanjan , Iran .
7
g Department of Medicinal Chemistry, School of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran .

Abstract

PURPOSE:

In this study, methoxy poly (ethylene glycol) -poly (ε-caprolactone) (mPEG-PCL) di block copolymers were synthesized. The purpose of this work is to investigate the in vivo anti-inflammatory effects of simvastatin-loaded micelles.

METHODS:

The structure of synthesized copolymers were characterized by using HNMR, FTIR and GPC techniques. Simvastatin was encapsulated in micelles through a single-step nano-precipitation method, leading to formation of simvastatin-loaded mPEG-PCL (simvastatin-mPEG-PCL) micelles. In this study the anti-inflammatory effects of simvastatin/mPEG-PCL micelles versus indomethacin were investigated in acute inflammation induced rats. The paw edema thickness was measured 1, 2, 3 and 4 hours after injection of formulation. The inhibition of edema in various groups were calculated and reported by percentages.

RESULTS:

The results showed that the zeta potential of micelles were about -14.9 ± 0.47 mV and the average size was in 66.10 ± 0.34 nm range. Simvastatin was encapsulated in mPEG-PCL micelles with loading capacity of 9.63 ± 0.87% and encapsulation efficiency of 64.20 ± 0.79%. Simvastatin and simvastatin-mPEG-PCL micelles showed significant anti-inflammatory activity in the present study.

CONCLUSIONS:

This study revealed that simvastatin and simvastatin/mPEG-PCL micelles both have anti-inflammatory effects and suggested that statins have potential anti-inflammatory activity along with their lipid lowering properties.

KEYWORDS:

Anti-inflammatory; Drug Delivery; Nanocarriers; Simvastatin; mPEG-PCL

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