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Knee. 2019 Jan;26(1):273-278. doi: 10.1016/j.knee.2018.11.014. Epub 2018 Nov 29.

Total knee arthroplasty in a patient with nail-patella syndrome (NPS).

Author information

1
McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States of America.
2
Houston Methodist Othopedics & Sports Medicine, Houston, TX, United States of America.
3
Houston Methodist Othopedics & Sports Medicine, Houston, TX, United States of America. Electronic address: sjincavo@houstonmethodist.org.

Abstract

Nail-patella syndrome (NPS) or hereditary onycho-osteodyaplasia is a rare genetic condition involving a mutation in the LMX1B gene affecting nails, elbows, knees, and pelvis. Due to the regulatory functions of the gene in many developmental processes through the body, patients with NPS experience wide-ranging musculoskeletal problems including patellar instability, fingernail anomalies, iliac exostoses/horns, and elbow abnormalities. The patellar changes often involve aplasia, hypoplasia, and chronic dislocation. Due to these musculoskeletal involvement, arthritis of joints can occur in patients with NPS causing severe pain and disability. This is a case report of a patient with NPS who underwent a total knee arthroplasty for symptomatic knee arthritis.

KEYWORDS:

Arthritis; Nail-patella syndrome; Onychoosteodysplasia; Patellar instability; Total knee arthroplasty

PMID:
30503662
DOI:
10.1016/j.knee.2018.11.014
[Indexed for MEDLINE]

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