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Infect Disord Drug Targets. 2018 Nov 25. doi: 10.2174/1871526519666181126094244. [Epub ahead of print]

Repurposing of existing drugs for the bacterial infections: An In silico and In vitro study.

Author information

1
Department of Biotechnology, ISF Institute of Professional Studies (ISFIPS), Moga, Punjab. India.
2
Department of Pharmacology, ISF College of Pharmacy (ISFCP), Moga, Punjab. India.

Abstract

BACKGROUND:

The emergence of infectious diseases and its resistance to approved drugs is a global threat to human health. The incidence of infectious diseases is increasing day by day and expected to rise exponentially in next 2 decades. Thus, there is a need for new treatment modalities for the treatment of microbial infections.

OBJECTIVE:

Thus, in the current investigation, we have explored the existing drugs [metformin (Anti-diabetic), propranolol (Anti-hypertensive), and amitriptyline (antidepressant)] for treatment of infectious diseases.

RESULTS:

An in-silico result of current investigation has shown the good interaction of metformin, propranolol, and amitriptyline towards various targets (Beta-lactamase, Penicillin-binding proteins, Staphylokinase protein, Oxidoreductase protein, etc.) of gram positive and gram negative bacteria as that of internal ligand. Further, in-vitro results have shown that the antibacterial activity of metformin, propranolol, and amitriptyline against Bacillus pumilus, Pseudomonas aeruginosa and Staphylococcus aureus.

CONCLUSION:

The parameters such as Microtiter assay: percentage growth retardation and bacterial growth kinetics, Minimum inhibitory concentration (MIC), Post-antibiotic assay and Biofilm formation have indicated the antibacterial potential of metformin, propranolol, and amitriptyline. However, before starting a clinical trial, complete safety and efficacy profile of drugs in the treatment of infectious diseases should be investigated.

KEYWORDS:

Drug repurposition; In silico; In vitro studies; Infectious diseases

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