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Trends Pharmacol Sci. 2018 Dec;39(12):1021-1032. doi: 10.1016/j.tips.2018.10.004.

Autophagy in Cancer: Regulation by Small Molecules.

Author information

1
NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; These authors contributed equally.
2
NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
3
Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, San Diego, La Jolla, CA, USA.
4
NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: ncosford@sbpdiscovery.org.

Abstract

During times of stress, autophagy is a cellular process that enables cells to reclaim damaged components by a controlled recycling pathway. This mechanism for cellular catabolism is dysregulated in cancer, with evidence indicating that cancer cells rely on autophagy in the hypoxic and nutrient-poor microenvironment of solid tumors. Mounting evidence suggests that autophagy has a role in the resistance of tumors to standard-of-care (SOC) therapies. Therefore, there is significant interest in the discovery of small molecules that can safely modulate autophagy. In this review, we describe recent advances in the identification of new pharmacological compounds that modulate autophagy, with a focus on their mode of action, value as probe compounds, and validation as potential therapeutics.

KEYWORDS:

autophagosome; autophagy; cancer; kinase; oncology

PMID:
30454769
PMCID:
PMC6349222
DOI:
10.1016/j.tips.2018.10.004
[Indexed for MEDLINE]
Free PMC Article

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