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J Biochem Mol Toxicol. 2019 Mar;33(3):e22260. doi: 10.1002/jbt.22260. Epub 2018 Nov 15.

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents.

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Division of Molecular Biology, Scientific and Technological Research and Application Center, Gaziosmanpasa University, Tokat, Turkey.
Department of Maths and Science Education, Faculty of Education, Kırıkkale University, Kırıkkale, Turkey.
Department of Basic Medical Sciences, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
Department of Chemistry, Faculty of Art and Science, Yıldız Technical University, Istanbul, Turkey.


Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.


apoptosis; cancer cells; cytotoxic activity; nitroquinoline; phenylquinoline; quinolines

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