Format

Send to

Choose Destination
J Biochem Mol Toxicol. 2019 Mar;33(3):e22260. doi: 10.1002/jbt.22260. Epub 2018 Nov 15.

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents.

Author information

1
Division of Molecular Biology, Scientific and Technological Research and Application Center, Gaziosmanpasa University, Tokat, Turkey.
2
Department of Maths and Science Education, Faculty of Education, Kırıkkale University, Kırıkkale, Turkey.
3
Department of Basic Medical Sciences, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
4
Department of Chemistry, Faculty of Art and Science, Yıldız Technical University, Istanbul, Turkey.

Abstract

Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.

KEYWORDS:

apoptosis; cancer cells; cytotoxic activity; nitroquinoline; phenylquinoline; quinolines

PMID:
30431695
DOI:
10.1002/jbt.22260
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center