Send to

Choose Destination
J Neurosci. 2018 Dec 5;38(49):10401-10410. doi: 10.1523/JNEUROSCI.2144-18.2018. Epub 2018 Oct 31.

Adult Hippocampal Neurogenesis: A Coming-of-Age Story.

Author information

University of Gothenburg, Institute for Neuroscience and Physiology, Section for Clinical Neuroscience, 40530 Gothenburg, Sweden.
Center for Stroke Research Berlin and Neurocure Cluster of Excellence, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, and.
Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, La Jolla, California 92037.
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, and


What has become standard textbook knowledge over the last decade was a hotly debated matter a decade earlier: the proposition that new neurons are generated in the adult mammalian CNS. The early discovery by Altman and colleagues in the 1960s was vulnerable to criticism due to the lack of technical strategies for unequivocal demonstration, quantification, and physiological analysis of newly generated neurons in adult brain tissue. After several technological advancements had been made in the field, we published a paper in 1996 describing the generation of new neurons in the adult rat brain and the decline of hippocampal neurogenesis during aging. The paper coincided with the publication of several other studies that together established neurogenesis as a cellular mechanism in the adult mammalian brain. In this Progressions article, which is by no means a comprehensive review, we recount our personal view of the initial setting that led to our study and we discuss some of its implications and developments that followed. We also address questions that remain regarding the regulation and function of neurogenesis in the adult mammalian brain, in particular the existence of neurogenesis in the adult human brain.


adult neurogenesis; aging; dentate gyrus; hippocampus

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center