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J Turk Ger Gynecol Assoc. 2018 Oct 26. doi: 10.4274/jtgga.2018.0119. [Epub ahead of print]

Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

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Department of Obstetrics and Gynecology, Udayana University, Sanglah General Hospital Faculty of Medicine, Bali, Indonesia


Ovarian cancer is one of the most common gynecologic cancer, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available which may explain the entire disease. Early detection and primary prevention of ovarian cancer are difficult, mostly due to its heterogeneous nature. Risk factor modification based on epidemiological data has not significantly reduced the incidence of ovarian cancer. Currently, prophylactic surgical methods have been proposed as the most effective preventive measures, for both the high-risk or low-risk populations. Understanding the existing pathogenesis theories and the surgical options available may alter clinician’s perspectives and facilitate better decision making.


ovarian cancer; primary prevention; salpingectomy; salpingo-oophorectomy

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