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Epigenomics. 2019 Feb;11(3):267-280. doi: 10.2217/epi-2018-0152. Epub 2018 Oct 26.

Integrated analysis of pseudogene RP11-564D11.3 expression and its potential roles in hepatocellular carcinoma.

Song H1,2, Yang J3,4, Zhang Y5, Zhou J1,2, Li Y3,4, Hao X3,4.

Author information

1
The Key Laboratory of Endemic & Ethnic Diseases, Guizhou Medical University, Ministry of Education, Guiyang 550004, PR China.
2
The Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guizhou Province, Guiyang 550004, PR China.
3
The State Key Laboratory of Functions & Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
4
The Key Laboratory of Chemistry for Natural Products of Guizhou Province & Chinese Academic of Sciences, Guiyang 550014, PR China.
5
School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, PR China.

Abstract

AIM:

We aim to identify differentially expressed pseudogenes and investigate their functional roles in carcinogenesis.

MATERIALS & METHODS:

Here, we identify dysregulated pseudogenes, analyze their prognostic values and investigate their potential functions through pseudogene-miRNA-mRNA network from public -omics repositories.

RESULTS:

We identified 16 frequently upregulated pseudogenes among which high expression levels of RP11-564D11.3 was significantly associated with poor overall survival in seven types of human cancers. RP11-564D11.3 was strongly correlated with pathways in cancer, PI3K-Akt signaling pathway and the neurotrophin signaling pathway. Further studies revealed that RP11-564D11.3 functions as a competitive endogenous RNA through targeting VEGFA in hepatocellular carcinoma.

CONCLUSION:

Our findings suggest RP11-564D11.3 as a novel biomarker and therapeutic potential target against hepatocellular carcinoma.

KEYWORDS:

; hepatocellular carcinoma; pseudogene

PMID:
30362374
DOI:
10.2217/epi-2018-0152
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