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Nat Rev Genet. 2019 Jan;20(1):39-50. doi: 10.1038/s41576-018-0063-5.

Coaching from the sidelines: the nuclear periphery in genome regulation.

Author information

1
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
2
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
3
Department of Physiology, University of California San Francisco, San Francisco, CA, USA.
4
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. hetzer@salk.edu.

Abstract

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. These genome regulatory roles of proteins of the nuclear periphery have important influences on development, disease and ageing.

PMID:
30356165
PMCID:
PMC6355253
DOI:
10.1038/s41576-018-0063-5
[Indexed for MEDLINE]
Free PMC Article

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