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J Exp Med. 2018 Nov 5;215(11):2697-2698. doi: 10.1084/jem.20181878. Epub 2018 Oct 18.

T-bet in Tfh cells: Now you see me, now you don't.

Author information

1
Salk Institute for Biological Studies, La Jolla, CA skaech@salk.edu.

Abstract

In this issue, Fang et al. (https://doi.org/10.1084/jem.20180927) report on a subset of T follicular helper (Tfh) cells that transiently expresses T-bet yet continues to produce IFN-γ at late stages of GC reactions following immunization. They find other genes uniquely expressed in this IFN-γ-producing Tfh subset, such as NKG2D, that can be used to better distinguish these functionally distinct Tfh cells.

PMID:
30337467
PMCID:
PMC6219747
DOI:
10.1084/jem.20181878
[Indexed for MEDLINE]
Free PMC Article

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