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Immunity. 2018 Oct 16;49(4):577-579. doi: 10.1016/j.immuni.2018.09.012.

Racheting Up Repair.

Author information

1
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla CA, USA.
2
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla CA, USA. Electronic address: dhargreaves@salk.edu.

Abstract

In this issue of Immunity, Daniel et al. (2018a) demonstrate that the nuclear receptor PPARγ acts in a ligand-insensitive manner to impart transcriptional memory and enhanced functionality to IL-4 polarized macrophages. Their findings shed light on the mechanisms that control priming of the epigenome in response to inflammatory signals.

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