Send to

Choose Destination
Proteomes. 2018 Oct 8;6(4). pii: E40. doi: 10.3390/proteomes6040040.

Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity.

Park J1,2.

Author information

Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA.


Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity.


AMPA receptor complex; phosphorylation; synaptic plasticity; transmembrane AMPA receptor regulatory protein

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center