Format

Send to

Choose Destination
Cell Metab. 2018 Oct 2;28(4):534-536. doi: 10.1016/j.cmet.2018.09.015.

AMPK Regulates the Epigenome through Phosphorylation of TET2.

Author information

1
Laboratory of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA.
2
Laboratory of Molecular and Cell Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address: shaw@salk.edu.

Abstract

Emerging evidence suggests that changes to cellular metabolism can regulate epigenetic modifications to alter gene expression. Recently in Nature, Wu et al. show that the metabolic regulator AMPK can phosphorylate and thus stabilize the epigenetic modifying enzyme TET2, defining a novel signaling link between metabolism and the epigenome.

PMID:
30282044
DOI:
10.1016/j.cmet.2018.09.015
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center