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Breast Cancer Res Treat. 2018 Sep 20. doi: 10.1007/s10549-018-4962-0. [Epub ahead of print]

Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions.

Author information

1
Massachusetts General Hospital, 55 Fruit Street, Yawkey 7, Boston, MA, 02114, USA.
2
Dana-Farber Cancer Institute, Boston, MA, USA.
3
Harvard T.H Chan School of Public Health, Boston, MA, USA.
4
Massachusetts Institute of Technology, Boston, MA, USA.
5
Massachusetts General Hospital, 55 Fruit Street, Yawkey 7, Boston, MA, 02114, USA. kshughes@partners.org.

Abstract

PURPOSE:

Mammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of atypical breast lesions and cancers in women of various ages in the largest mammoplasty cohort reported to date.

METHODS:

We analyzed pathologic reports from patients undergoing bilateral mammoplasty, using natural language processing algorithm, verified by human review. Patients with a prior history of breast cancer or atypia were excluded.

RESULTS:

A total of 4775 patients were deemed eligible. Median age was 40 (range 13-86) and was higher in patients with any incidental finding compared to patients with normal reports (52 vs. 39 years, pā€‰=ā€‰0.0001). Pathological findings were detected in 7.06% (337) of procedures. Benign high-risk lesions were found in 299 patients (6.26%). Invasive carcinoma and ductal carcinoma in situ were detected in 15 (0.31%) and 23 (0.48%) patients, respectively. The rate of atypias and cancers increased with age.

CONCLUSION:

The overall rate of abnormal findings in asymptomatic patients undergoing mammoplasty was 7.06%, increasing with age. As these results are based on random sample of breast tissue, they likely underestimate the prevalence of abnormal findings in asymptomatic women.

KEYWORDS:

Breast; Breast diseases; Breast neoplasm; Epidemiology; Mammaplasty

PMID:
30238276
DOI:
10.1007/s10549-018-4962-0

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