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Clin Implant Dent Relat Res. 2018 Dec;20(6):923-928. doi: 10.1111/cid.12667. Epub 2018 Sep 19.

Autogenous DDM versus Bio-Oss granules in GBR for immediate implantation in periodontal postextraction sites: A prospective clinical study.

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School of Stomatology and Medicine, Foshan University, Foshan, Guangdong, P.R. China.



Demineralized dentin matrix (DDM) from the patient's own extracted healthy tooth can be recycled as an autogenous biomaterial for reconstructive dentistry. The aim of the present study was to evaluate the clinical efficacy of autogenous DDM versus Bio-Oss granules in guided bone regeneration (GBR) for immediate implantation in periodontal postextraction sites.


From November 2015 to March 2017, patients referred to the Foshan Stomatology Hospital, who had been diagnosed with severe periodontitis of the posterior mandibular tooth and agreed to dental implant treatment, were consecutively included. The patients were randomly allocated to the DDM group, treated with immediate implantation + GBR with autogenous DDM granules from the extracted tooth, or the BIO group, treated with immediate implantation + GBR with Bio-Oss granules. The implant stability and marginal bone resorption were measured immediately, at 6 and 18 months after surgery.


Forty patients (45 implants) were included. Except 2 cases with wound infection, 43 implants did not have postoperative complications and achieved a satisfactory outcome after 1-year prosthetic loading. There was no statistically significant difference between the 2 groups in implant stability quotient values and marginal bone resorption.


The autogenous DDM granules prepared at the chairside after extractions could act as an excellent readily available alternative to bone graft material in GBR, even for implantation of severe periodontitis cases.


demineralized dentin matrix; guided bone regeneration; immediate implantation; periodontitis


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