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J Turk Ger Gynecol Assoc. 2018 Sep 11. doi: 10.4274/jtgga.2017.0133. [Epub ahead of print]

Spontaneous and IVF pregnancies have comparable first trimester screening profiles for Down syndrome

Author information

1
Assisted Reproduction Unit, American Hospital Women's Health Center, İstanbul, Turkey.
2
Department of Obstetrics and Gynecology, Koç University School of Medicine, İstanbul, Turkey.

Abstract

OBJECTIVE:

We aimed to compare the first trimester screening profiles of spontaneous (n=972) and IVF pregnancies (n=339) in a population of patients who had uncomplicated singleton pregnancies comparable for maternal age, gestation, BMI, and ethnicity.

MATERIAL AND METHODS:

A non-interventional analysis of retrospective cohort data and review of the literature.

RESULTS:

All IVF pregnancies were achieved via ICSI using the same ovarian stimulation protocol with recombinant FSH and a GnRH antagonist, cetrorelix acetate. The means of the multiple of median (MoM) of PAPP-A were slightly lower in the fresh (1.19±0.6 vs. 1.33±0.7, respectively; p=0.056) and frozen ET (1.03±0.5 vs. 1.33±0. 7, respectively; p=0.036) IVF pregnancies compared with natural conceptions. However, when the medians of the MoMs of PAPP-A and β-hCG, and their distributions were compared across the mode of conception, there were no differences between IVF pregnancies spontaneous pregnancies. Furthermore, the scatterplot diagram and curve fitting regression analyses revealed no difference in the temporal relations of β-hCG and PAPP-A with each other and gestational age between spontaneous and IVF pregnancies.

CONCLUSION:

These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous conceptions.

KEYWORDS:

First trimester screening; IVF ICSI.; NT; PAPP-A; Pregnancy; β-hCG

PMID:
30206047
DOI:
10.4274/jtgga.2017.0133
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