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Brain Struct Funct. 2018 Dec;223(9):4169-4186. doi: 10.1007/s00429-018-1738-6. Epub 2018 Sep 5.

Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas.

Author information

1
C. and O. Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
2
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
3
Centre of Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
4
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
5
Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen, and JARA Translational Brain Medicine, Aachen, Germany.
6
Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
7
Institute for Neuroscience and Medicine (INM-7), Research Centre Jülich, Jülich, Germany.
8
Centre of Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. seitz@neurologie.uni-duesseldorf.de.
9
Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany. seitz@neurologie.uni-duesseldorf.de.
10
Florey Neuroscience Institutes, Melbourne, VIC, Australia. seitz@neurologie.uni-duesseldorf.de.

Abstract

The dorsal  mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence between the two subregions. However, a microstructural map of these areas obtained in a representative sample of brains in a stereotaxic reference space is still lacking. In the present study we show that the dorsal mesial frontal motor cortex comprises two microstructurally different brain regions: area SMA and area pre-SMA. Area-specific cytoarchitectonic patterns were studied in serial histological sections stained for cell bodies of ten human postmortem brains. Borders of the two cortical areas were identified using image analysis and statistical features. The 3D reconstructed areas were transferred to a common reference space, and probabilistic maps were calculated by superimposing the individual maps. A coordinate-based meta-analysis of functional imaging data was subsequently performed using the two probabilistic maps as microstructurally defined seed regions. It revealed that areas SMA and pre-SMA were strongly co-activated with areas in precentral, supramarginal and superior frontal gyri, Rolandic operculum, thalamus, putamen and cerebellum. Both areas were related to motor functions, but area pre-SMA was involved in more complex processes such as learning, cognitive processes and perception. The here described subsequent analyses led to converging evidence supporting the microstructural, and functional segregation of areas SMA and pre-SMA, and maps will be made available to the scientific community to further elucidate the microstructural substrates of motor and cognitive control.

KEYWORDS:

Cytoarchitectonic mapping; Meta-analytic connectivity modeling; Pre-supplementary motor area; Probability maps; Quantitative cytoarchitectonics; Supplementary motor area

PMID:
30187192
PMCID:
PMC6267244
DOI:
10.1007/s00429-018-1738-6
[Indexed for MEDLINE]
Free PMC Article

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