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Cell Metab. 2018 Sep 4;28(3):330-331. doi: 10.1016/j.cmet.2018.08.017.

A Mitochondrial-Derived Peptide Exercises the Nuclear Option.

Author information

1
Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
2
Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gshadel@salk.edu.

Abstract

The vast majority of mitochondrial proteins are encoded by nuclear genes, giving the nucleus ultimate control of mitochondrial biogenesis, dynamics, and function. However, in this issue Kim et al. (2018) demonstrate a reversal of fortune, whereby an mtDNA-encoded peptide, MOTS-c, is targeted to the nucleus to signal changes in gene expression.

PMID:
30184481
DOI:
10.1016/j.cmet.2018.08.017
[Indexed for MEDLINE]
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