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Clin Infect Dis. 2019 Mar 5;68(6):1044-1047. doi: 10.1093/cid/ciy764.

Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial.

Author information

1
Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco.
2
Department of Epidemiology and Biostatistics, University of California, San Francisco.
3
Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia.
4
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
5
Division of Infectious Diseases, Department of Medicine, Vanderbilt University.
6
Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee.
7
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco.
8
Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles.

Abstract

Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).

KEYWORDS:

A5257 study; AIDS Clinical Trials Group (ACTG); HIV; hair concentrations; non-NNRTI regimens

PMID:
30184104
PMCID:
PMC6399433
[Available on 2019-09-03]
DOI:
10.1093/cid/ciy764

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