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J Clin Res Pediatr Endocrinol. 2018 Sep 4. doi: 10.4274/jcrpe.0149. [Epub ahead of print]

Birth Sizes of Neonates with Congenital Adrenal Hyperplasia Secondary to 21-Hydroxylase Deficiency.

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University Hospital of Erlangen, Department of Paediatrics, Division of Paediatric Endocrinology, Germany.



Classic congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency (CAH) is characterized by increased prenatal adrenal androgen secretion. There are few reports in the literature showing higher birth weight and length in CAH newborns.


We analyzed birth weight and length data of 116 German newborns (48 boys, 68 girls) with classic CAH who were born during the period from 1990 to 2017. All children have been followed or are currently treated as outpatients in our clinic. All children were born at term. The mothers were 2 healthy, and their pregnancies were uneventful. The diagnosis of CAH was confirmed by molecular analyses of the CYP21A2 gene. Birth data were calculated as standard deviation scores (SDS) according to German reference values.


(Mean ± SD): Weight and length in male CAH newborns (3601 ± 576 g; 52.4 ± 2.85 cm) were statistically significantly higher than in female CAH newborns (3347 ± 442 g; 51.2 ± 2.55 cm), but male-female differences in the CAH cohort were lost when data were converted into SD scores. The birth sizes of the CAH newborns did not differ from the reference group. The birth sizes were not different in relation to the different CAH genotypes. Maternal age, mode of delivery and maternal parity had no influence on birth sizes.


Our data show that prenatal hyperandrogenism does not affect fetal growth.


21-hydroxylase deficiency genotype.; Term newborn; congenital adrenal hyperplasia

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