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J Cell Biol. 2018 Oct 1;217(10):3327-3329. doi: 10.1083/jcb.201808118. Epub 2018 Aug 28.

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.

Author information

1
The Salk Institute for Biological Studies, La Jolla, CA.
2
The Salk Institute for Biological Studies, La Jolla, CA gshadel@salk.edu.

Abstract

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS-STING pathway that may contribute to Parkinson's disease.

PMID:
30154188
PMCID:
PMC6168260
DOI:
10.1083/jcb.201808118
[Indexed for MEDLINE]
Free PMC Article

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