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Virchows Arch. 2018 Nov;473(5):591-598. doi: 10.1007/s00428-018-2444-8. Epub 2018 Aug 23.

L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition.

Author information

1
Department of Gynecology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. m.a.c.versluis@umcg.nl.
2
Department of Gynecology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
3
Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Arnau de Vilanova University Hospital, IRBLleida, University of Lleida, Lleida, Spain.
4
Centro de Investigación Biomédica en Red de Oncología (CIBERONC), Madrid, Spain.
5
Department of Pathology, University Hospital of Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Catalonia, Spain.
6
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
7
Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Bergen, Norway.
8
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
9
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
10
Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Abstract

Uterine carcinosarcoma (UCS) has been proposed as a model for epithelial-mesenchymal transition (EMT), a process characterized by a functional change facilitating migration and metastasis in many types of cancer. L1CAM is an adhesion molecule that has been involved in EMT as a marker for mesenchymal phenotype. We examined expression of L1CAM in UCS in a cohort of 90 cases from four different centers. Slides were immunohistochemically stained for L1CAM and scored in four categories (0%, < 10%, 10-50%, and > 50%). A score of more than 10% was considered positive for L1CAM. The median age at presentation was 68.6 years, and half of the patients (53.3%) presented with FIGO stage 1 disease. Membranous L1CAM expression was positive in the epithelial component in 65.4% of cases. Remarkably, expression was negative in the mesenchymal component. In cases where both components were intermingled, expression limited to the epithelial component was confirmed by a double stain for L1CAM and keratin. Expression of L1CAM did not relate to overall or disease-free survival. Our findings suggest L1CAM is either not a marker for the mesenchymal phenotype in EMT, or UCS is not a good model for EMT.

KEYWORDS:

Endometrial neoplasm; Epithelial–mesenchymal transition; Histology; L1CAM; Neural cell adhesion molecule L1

PMID:
30140948
DOI:
10.1007/s00428-018-2444-8
[Indexed for MEDLINE]

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