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Nat Commun. 2018 Aug 22;9(1):3362. doi: 10.1038/s41467-018-05871-5.

Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis.

Author information

1
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
2
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA. quan.yuan@nih.gov.

Abstract

Highly motile dendritic protrusions are hallmarks of developing neurons. These exploratory filopodia sample the environment and initiate contacts with potential synaptic partners. To understand the role for dynamic filopodia in dendrite morphogenesis and experience-dependent structural plasticity, we analyzed dendrite dynamics, synapse formation, and dendrite volume expansion in developing ventral lateral neurons (LNvs) of the Drosophila larval visual circuit. Our findings reveal the temporal coordination between heightened dendrite dynamics with synaptogenesis in LNvs and illustrate the strong influence imposed by sensory experience on the prevalence of dendritic filopodia, which regulate the formation of synapses and the expansion of dendritic arbors. Using genetic analyses, we further identified Amphiphysin (Amph), a BAR (Bin/Amphiphysin/Rvs) domain-containing protein as a required component for tuning the dynamic state of LNv dendrites and promoting dendrite maturation. Taken together, our study establishes dynamic filopodia as the key cellular target for experience-dependent regulation of dendrite development.

PMID:
30135566
PMCID:
PMC6105721
DOI:
10.1038/s41467-018-05871-5
[Indexed for MEDLINE]
Free PMC Article

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