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J Infect Dis. 2018 Nov 5;218(12):1937-1942. doi: 10.1093/infdis/jiy454.

Genetic Diversity of Noroviruses Circulating in a Pediatric Cohort in Bangladesh.

Author information

1
Fogarty International Center, National Institutes of Health, Bethesda, Maryland.
2
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka.
3
Centers for Disease Control and Prevention, Atlanta, Georgia.
4
Synergy, Atlanta, Georgia.

Abstract

Noroviruses are a leading cause of diarrhea in children aged <5 years worldwide. We genotyped 88 viruses collected by active surveillance in a birth cohort of children <2 years of age in Dhaka, Bangladesh, during 2010-2013. Twenty-five of 31 (81%) established GI and GII genotypes were detected, with GII.4 as the predominant genotype (20%). Our results show that children in Bangladesh are infected with a great diversity of norovirus strains. Reinfections are common, but not with closely related genotypes. Birth cohort studies are critical to understand cross-protective immunity and advance the development of pediatric norovirus vaccines.

PMID:
30053045
PMCID:
PMC6217719
[Available on 2019-11-05]
DOI:
10.1093/infdis/jiy454
[Indexed for MEDLINE]

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