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Page 1
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Kim SG, Novak RF. Kim SG, et al. Cancer Res. 1990 Sep 1;50(17):5333-9. Cancer Res. 1990. PMID: 2167153
The metabolism of 3-hydroxypyridine, a significant constituent of tobacco smoke, to 2,5-dihydroxypyridine has been characterized in hepatic microsomes and in the reconstituted enzyme system using purified forms of P450. ...P450IIE1 was 34-fold more active tha …
The metabolism of 3-hydroxypyridine, a significant constituent of tobacco smoke, to 2,5-dihydroxypyridine has been char …
Novel 3,6-Dihydroxypicolinic Acid Decarboxylase-Mediated Picolinic Acid Catabolism in Alcaligenes faecalis JQ135.
Qiu J, Zhang Y, Yao S, Ren H, Qian M, Hong Q, Lu Z, He J. Qiu J, et al. J Bacteriol. 2019 Mar 13;201(7):e00665-18. doi: 10.1128/JB.00665-18. Print 2019 Apr 1. J Bacteriol. 2019. PMID: 30692170 Free PMC article.
The PicC was Zn(2+)-dependent nonoxidative decarboxylase that can specifically catalyze the irreversible decarboxylation of 3,6DHPA to 2,5-dihydroxypyridine. The K(m) and k(cat) toward 3,6DHPA were observed to be 13.44 muM and 4.77 s(-1), respectively. …
The PicC was Zn(2+)-dependent nonoxidative decarboxylase that can specifically catalyze the irreversible decarboxylation of 3,6DHPA t …
Isolation of a 3-hydroxypyridine degrading bacterium, Agrobacterium sp. DW-1, and its proposed degradation pathway.
Zhao S, Hu C, Guo L, Li K, Yu H. Zhao S, et al. AMB Express. 2019 May 17;9(1):65. doi: 10.1186/s13568-019-0782-9. AMB Express. 2019. PMID: 31102032 Free PMC article.
The optimal cultivation temperature and pH for strain DW-1 with 3-hydroxypyridine were 30 C and 8.0, respectively. Under optimal conditions, strain DW-1 could completely degrade up to 1500 mg/L of 3-hydroxypyridine in 66 h. ...The first reaction of 3-hydroxyp …
The optimal cultivation temperature and pH for strain DW-1 with 3-hydroxypyridine were 30 C and 8.0, respectively. Under optimal cond …
Pusillimonas sp. 5HP degrading 5-hydroxypicolinic acid.
Karvelis L, Gasparavičiūtė R, Klimavičius A, Jančienė R, Stankevičiūtė J, Meškys R. Karvelis L, et al. Biodegradation. 2014 Feb;25(1):11-9. doi: 10.1007/s10532-013-9636-3. Epub 2013 Mar 30. Biodegradation. 2014. PMID: 23543363
Both the bioconversion analysis using resting cells and the enzymatic assay showed that the degradation of 5-hydroxypicolinic acid, 3-hydroxypyridine and nicotinic acid was inducible and proceeded via formation of the same metabolite, 2,5-dihydroxypyridine. . …
Both the bioconversion analysis using resting cells and the enzymatic assay showed that the degradation of 5-hydroxypicolinic acid, 3 …
A preliminary crystallographic study of recombinant NicX, an Fe(2+)-dependent 2,5-dihydroxypyridine dioxygenase from Pseudomonas putida KT2440.
Jiménez JI, Acebrón I, García JL, Díaz E, Mancheño JM. Jiménez JI, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt 5):549-53. doi: 10.1107/S174430911001119X. Epub 2010 Apr 29. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20445257 Free PMC article.
NicX from Pseudomonas putida KT2440 is an Fe(2+)-dependent dioxygenase that is involved in the aerobic degradation of nicotinic acid. The enzyme converts 2,5-dihydroxypyridine to N-formylmaleamic acid when overexpressed in Escherichia coli. ...The crystals most prob …
NicX from Pseudomonas putida KT2440 is an Fe(2+)-dependent dioxygenase that is involved in the aerobic degradation of nicotinic acid. The en …
Catabolism of 2-Hydroxypyridine by Burkholderia sp. Strain MAK1: a 2-Hydroxypyridine 5-Monooxygenase Encoded by hpdABCDE Catalyzes the First Step of Biodegradation.
Petkevičius V, Vaitekūnas J, Stankevičiūtė J, Gasparavičiūtė R, Meškys R. Petkevičius V, et al. Appl Environ Microbiol. 2018 May 17;84(11):e00387-18. doi: 10.1128/AEM.00387-18. Print 2018 Jun 1. Appl Environ Microbiol. 2018. PMID: 29602788 Free PMC article.
We have proved that the recombinant HpdABCDE protein catalyzes the enzymatic turnover of 2-hydroxypyridine to 2,5-dihydroxypyridine. Moreover, we have confirmed that emerging 2,5-dihydroxypyridine is a substrate for HpdF, an enzyme similar to 2,5 …
We have proved that the recombinant HpdABCDE protein catalyzes the enzymatic turnover of 2-hydroxypyridine to 2,5-dihydroxypyridin …
Mechanism of 6-Hydroxynicotinate 3-Monooxygenase, a Flavin-Dependent Decarboxylative Hydroxylase Involved in Bacterial Nicotinic Acid Degradation.
Nakamoto KD, Perkins SW, Campbell RG, Bauerle MR, Gerwig TJ, Gerislioglu S, Wesdemiotis C, Anderson MA, Hicks KA, Snider MJ. Nakamoto KD, et al. Biochemistry. 2019 Apr 2;58(13):1751-1763. doi: 10.1021/acs.biochem.8b00969. Epub 2019 Mar 12. Biochemistry. 2019. PMID: 30810301
6-Hydroxynicotinate 3-monooxygenase (NicC) is a Group A FAD-dependent monooxygenase that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH in nicotinic acid deg …
6-Hydroxynicotinate 3-monooxygenase (NicC) is a Group A FAD-dependent monooxygenase that catalyzes the decarboxylative hydroxylation …
Biodegradation of nicotine by a novel strain Pusillimonas.
Ma Y, Wen R, Qiu J, Hong J, Liu M, Zhang D. Ma Y, et al. Res Microbiol. 2015 Feb-Mar;166(2):67-71. doi: 10.1016/j.resmic.2014.12.009. Epub 2014 Dec 27. Res Microbiol. 2015. PMID: 25546833 Free article.
Six intermediates were detected and identified as 6-hydroxy-nicotine, 6-hydroxy-N-methylmyosmine, 6-hydroxypseudooxynicotine, 2,6-dihydroxypyridine, 6-hydroxy-3-succinoyl-pyridine and 2,5-dihydroxypyridine. Activities of 6-hydroxy-3-succinoyl-pyridine …
Six intermediates were detected and identified as 6-hydroxy-nicotine, 6-hydroxy-N-methylmyosmine, 6-hydroxypseudooxynicotine, 2,6-dihydroxyp …
Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16.
Yu H, Hausinger RP, Tang HZ, Xu P. Yu H, et al. J Biol Chem. 2014 Oct 17;289(42):29158-70. doi: 10.1074/jbc.M114.558049. Epub 2014 Aug 29. J Biol Chem. 2014. PMID: 25172510 Free PMC article.
6-Hydroxy-3-succinoyl-pyridine (HSP) 3-monooxygenase (HspB), a flavoprotein essential to the pyrrolidine pathway of nicotine degradation, catalyzes pyridine-ring beta-hydroxylation, resulting in carbon-carbon cleavage and production of 2,5-dihydroxypyridin …
6-Hydroxy-3-succinoyl-pyridine (HSP) 3-monooxygenase (HspB), a flavoprotein essential to the pyrrolidine pathway of nicotine d …
Expression and Characterization of 3,6-Dihydroxy-picolinic Acid Decarboxylase PicC of Bordetella bronchiseptica RB50.
Yuan C, Zhao L, Tong L, Wang L, Ke Z, Yang Y, He J. Yuan C, et al. Microorganisms. 2023 Mar 27;11(4):854. doi: 10.3390/microorganisms11040854. Microorganisms. 2023. PMID: 37110277 Free PMC article.
The organization of pic gene cluster of strain RB50 was found to be similar with that of Alcaligenes faecalis, in which the sequence similarities of each Pic proteins are between 60% to 80% except for PicB2 (47% similarity). The 3,6-dihydroxypicolinic acid (3,6DHPA) …
The organization of pic gene cluster of strain RB50 was found to be similar with that of Alcaligenes faecalis, in which the sequence similar …
21 results