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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1992 4
1994 3
1995 6
1996 6
1997 7
1998 10
1999 12
2000 7
2001 7
2002 9
2003 11
2004 13
2005 16
2006 18
2007 21
2008 24
2009 22
2010 39
2011 85
2012 73
2013 43
2014 27
2015 27
2016 35
2017 51
2018 39
2019 72
2020 54
2021 24
2022 29
2023 28
2024 7

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702 results

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Page 1
Fragile X syndrome: a review of clinical and molecular diagnoses.
Ciaccio C, Fontana L, Milani D, Tabano S, Miozzo M, Esposito S. Ciaccio C, et al. Ital J Pediatr. 2017 Apr 19;43(1):39. doi: 10.1186/s13052-017-0355-y. Ital J Pediatr. 2017. PMID: 28420439 Free PMC article. Review.
It is caused by an alteration of the FMR1 gene, which maps at the Xq27.3 band: more than 99% of individuals have a CGG expansion (>200 triplets) in the 5' UTR of the gene, and FMR1 mutations and duplication/deletion are responsible for the remaining (<1%) mole …
It is caused by an alteration of the FMR1 gene, which maps at the Xq27.3 band: more than 99% of individuals have a CGG expansion (&gt …
3'UTRs take a long shot in the brain.
Wang L, Yi R. Wang L, et al. Bioessays. 2014 Jan;36(1):39-45. doi: 10.1002/bies.201300100. Epub 2013 Sep 20. Bioessays. 2014. PMID: 24115048 Free PMC article. Review.
The fast advancing RNA-seq technology has unveiled an unexpected diversity and expression specificity of 3' untranslated regions (3'UTRs) of mRNAs. In particular, neural mRNAs seem to express significantly longer 3'UTRs, some of which are over 10 kb in length …
The fast advancing RNA-seq technology has unveiled an unexpected diversity and expression specificity of 3' untranslated regions ( …
3'UTR-CDKN2A and CDK4 Germline Variants Are Associated With Susceptibility to Cutaneous Melanoma.
Tovar-Parra D, Gil-Quiñones SR, Nova J, Gutiérrez-Castañeda LD. Tovar-Parra D, et al. In Vivo. 2021 May-Jun;35(3):1529-1536. doi: 10.21873/invivo.12406. In Vivo. 2021. PMID: 33910831 Free PMC article.
The CDKN2A variants were present in 36% of acral lentiginous melanoma and 39.47% of lentigo maligna. The haplotype analysis showed an association with susceptibility in the development of melanoma. ...
The CDKN2A variants were present in 36% of acral lentiginous melanoma and 39.47% of lentigo maligna. The haplotype analysis showed an …
YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation.
Zhang C, Huang S, Zhuang H, Ruan S, Zhou Z, Huang K, Ji F, Ma Z, Hou B, He X. Zhang C, et al. Oncogene. 2020 Jun;39(23):4507-4518. doi: 10.1038/s41388-020-1303-7. Epub 2020 May 4. Oncogene. 2020. PMID: 32366907
Mechanistically, the knockdown and overexpression of YTHDF2 in liver cancer cells resulted in decreased and increased m6A levels in the 5'-untranslated region (UTR) of OCT4 mRNA, respectively, leading to decreased and increased OCT4 protein expression, respectively. A luci …
Mechanistically, the knockdown and overexpression of YTHDF2 in liver cancer cells resulted in decreased and increased m6A levels in the 5'-u …
Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population.
Egeli U, Ak S, Cecener G, Tunca B, Tezcan G, Sevinc ED, Kaya E, Dundar HZ, Sarkut P, Ozen Y, Balcin O, Evrensel T, Yerci O, Ugras N. Egeli U, et al. Pancreatology. 2016 Jul-Aug;16(4):677-86. doi: 10.1016/j.pan.2016.05.004. Epub 2016 May 24. Pancreatology. 2016. PMID: 27256640
OBJECTIVE: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the KRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). ... …
OBJECTIVE: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslate …
Spliceostatin A stabilizes CDKN1B mRNA through the 3' UTR.
Kaida D, Shida K. Kaida D, et al. Biochem Biophys Res Commun. 2022 Jun 11;608:39-44. doi: 10.1016/j.bbrc.2022.03.085. Epub 2022 Mar 29. Biochem Biophys Res Commun. 2022. PMID: 35381427
SSA did not affect transcription of CDKN1B gene, but stabilized CDKN1B mRNA. Finally, we revealed that the 3' untranslated region of CDKN1B mRNA was involved in the stabilization. ...
SSA did not affect transcription of CDKN1B gene, but stabilized CDKN1B mRNA. Finally, we revealed that the 3' untranslated region of …
Alternative Polyadenylation of mRNAs: 3'-Untranslated Region Matters in Gene Expression.
Yeh HS, Yong J. Yeh HS, et al. Mol Cells. 2016 Apr 30;39(4):281-5. doi: 10.14348/molcells.2016.0035. Epub 2016 Feb 25. Mol Cells. 2016. PMID: 26912084 Free PMC article. Review.
Recent discoveries showed that many of these mRNAs contain more than one polyadenylation sites in their 3' untranslated regions (UTR) and that alternative polyadenylation (APA) is prevalent among these genes. Many biological processes such as differentiation, prolif …
Recent discoveries showed that many of these mRNAs contain more than one polyadenylation sites in their 3' untranslated regions (U …
Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy.
Zafra G, Morillo C, Martín J, González A, González CI. Zafra G, et al. Microbes Infect. 2007 Jul;9(9):1049-52. doi: 10.1016/j.micinf.2007.04.010. Epub 2007 May 3. Microbes Infect. 2007. PMID: 17644387 Free article.
Interestingly, we found that the IL12B 3' UTR CC genotype was significantly increased among cardiomyopathic patients when compared to asymptomatic individuals (16% versus 5%; P=0.005; P(c)=0.015; OR=3.39; 95% CI 1.3-9.15). ...Our results suggest …
Interestingly, we found that the IL12B 3' UTR CC genotype was significantly increased among cardiomyopathic patients when comp …
Polymorphism of ITGB2 gene 3'-UTR+145C/A is associated with biliary atresia.
Zhao R, Song Z, Dong R, Li H, Shen C, Zheng S. Zhao R, et al. Digestion. 2013;88(2):65-71. doi: 10.1159/000352025. Epub 2013 Aug 6. Digestion. 2013. PMID: 23921155
There were no significant differences in genotype and allelic frequencies of any of the SNPs between controls and patients with BA in both the promoter and exons 1, 3, 7, and 10. 3'-UTR+145C/A showed a significant increase in the C allele frequency (OR = 2.19 …
There were no significant differences in genotype and allelic frequencies of any of the SNPs between controls and patients with BA in both t …
RNA-biology ruling cancer progression? Focus on 3'UTRs and splicing.
Erson-Bensan AE. Erson-Bensan AE. Cancer Metastasis Rev. 2020 Sep;39(3):887-901. doi: 10.1007/s10555-020-09884-9. Cancer Metastasis Rev. 2020. PMID: 32361913 Review.
Recently, these rather overlooked regions of mRNAs are gaining attention as mounting evidence provides functional links between 3'UTRs, protein functions, and cancer-related molecular mechanisms. Here, roles of 3'UTRs in cancer biology and mechanisms that result in …
Recently, these rather overlooked regions of mRNAs are gaining attention as mounting evidence provides functional links between 3'UTR …
702 results