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Adv Exp Med Biol. 2018;1068:177-185. doi: 10.1007/978-981-13-0502-3_15.

Roles of Single Cell Systems Biomedicine in Lung Diseases.

Author information

1
Department of Respiratory Pulmonary and Critical Care Medicine, The Second Hospital of Fujian Medical University, Quanzhou, Fujian Province, China. zeng_yi_ming@126.com.
2
Department of Respiratory Pulmonary and Critical Care Medicine, The Second Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
3
Department of Respiratory Pulmonary and Critical Care Medicine, The Second Hospital of Fujian Medical University, Quanzhou, Fujian Province, China. Xiangdong.wang@clintransmed.org.

Abstract

Single cell sequencing is important to detect the gene heterogeneity between cells, as the part of single-cell systems biology which combines computational science, mathematical modelling and high-throughput technologies with biological function and organization in the cell. We initially arise the question how to integrate the outcomes of single-cell systems biology with clinical phenotype, interpret alterations of single-cell gene sequencing and function in patient response to therapies, and understand the significance of single-cell systems biology in the discovery and development of new molecular diagnostics and therapeutics. The present review furthermore focuses the significance of singe cell systems biology in respiratory diseases and calls the special attention from scientists who are working on single cell systems biology to improve the diagnosis and therapy for patients with lung diseases.

KEYWORDS:

COPD; Cancer; Diagnosis; Lung; Single cell

PMID:
29943305
DOI:
10.1007/978-981-13-0502-3_15
[Indexed for MEDLINE]

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