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Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11.

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

Author information

1
SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
2
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
3
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
4
Centre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC, Canada.
5
Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
6
Chulalongkorn Vaccine Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
7
Department of Medicine, Division of Infectious Diseases & HIV Medicine at Drexel University College of Medicine, Philadelphia, PA, USA.
8
HIV-NAT, Thai Red Cross AIDS Research Center, Bangkok, Thailand.
9
AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
10
Division of AIDS, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
11
Department of Retrovirology, Armed Forces Research Institute of Medical Sciences United States Component, Bangkok, Thailand.
12
International Vaccine Institute, Seoul, Korea.
13
SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand. jananworanich@hivresearch.org.
14
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. jananworanich@hivresearch.org.
15
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA. jananworanich@hivresearch.org.
16
Department of Global Health, University of Amsterdam, Amsterdam, the Netherlands. jananworanich@hivresearch.org.

Abstract

Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.

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