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Mol Cell. 2018 Jun 7;70(5):759-760. doi: 10.1016/j.molcel.2018.05.027. Epub 2018 Jun 7.

Toxins that Trash Translation.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: buskirk@jhmi.edu.

Abstract

Culviner and Laub (2018) use RNA-seq and ribosome profiling to determine how MazF inhibits translation in E. coli. Challenging an earlier model, they argue that MazF cleaves mRNA and blocks ribosome biogenesis but does not generate specialized ribosomes that preferentially translate leaderless transcripts.

PMID:
29883601
PMCID:
PMC6188653
DOI:
10.1016/j.molcel.2018.05.027
[Indexed for MEDLINE]
Free PMC Article

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