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Curr Opin Genet Dev. 2018 Oct;52:36-41. doi: 10.1016/j.gde.2018.05.007. Epub 2018 May 30.

Interspecies chimeras.

Author information

1
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States.
2
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States; Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan. Electronic address: nakauchi@stanford.edu.

Abstract

By probing early embryogenesis and regeneration, interspecies chimeras provide a unique platform for discovery and clinical use. Although efficient generation of human:animal chimeric embryos remains elusive, recent advancements attempt to overcome incompatibilities in xenogeneic development and transplantation.

PMID:
29859382
DOI:
10.1016/j.gde.2018.05.007
[Indexed for MEDLINE]

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