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J Clin Res Pediatr Endocrinol. 2018 May 23. doi: 10.4274/jcrpe.0025. [Epub ahead of print]

Incidence of Type 1 Diabetes in Children Aged Below 18 Years During 2013-2015 in Northwest Turkey.

Author information

1
İstanbul University, Istanbul Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
2
University of Kyrenia, Faculty of Medicine, Pediatric Endocrinology Unit, Kyrenia, Turkish Republic of North Cyprus.
3
Kanuni Sultan Suleyman Training and Research Hospital, Department of Pediatric Endocrinology and Metabolic Disease, Istanbul, Turkey.
4
Marmara University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
5
Kartal Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
6
Uludag University, Faculty of Medicine, Pediatric Endocrinology Unit, Bursa, Turkey.
7
Amasya University, Faculty of Medicine, Amasya, Turkey.
8
Goztepe Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
9
Kocaeli University, Faculty of Medicine, Pediatric Endocrinology Unit, Kocaeli, Turkey.
10
Koc University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
11
Bezmialem Vakif University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
12
Trakya University, Faculty of Medicine, Pediatric Endocrinology Unit, Edirne, Turkey.
13
Bakirkoy Dr Sadi Konuk Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
14
Sevket Yılmaz Training and Research Hospital, Pediatric Endocrinology Unit, Bursa, Turkey.
15
Istanbul University, Cerrahpasa Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
16
Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
17
Umraniye Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
18
Duzce University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
19
Sakarya University, Faculty of Medicine, Pediatric Endocrinology Unit, Sakarya, Turkey.
20
Haseki Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
21
Medipol University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
22
Sisli Etfal Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
23
Derince Training and Research Hospital, Pediatric Endocrinology Unit, Kocaeli, Turkey.
24
Okmeydani Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
25
Çorlu State Hospital, Pediatric Endocrinology Unit, Tekirdag, Turkey.
26
Acibadem University, Faculty of Medicine, Pediatric Endocrinology Unit, Istanbul, Turkey.
27
Balikesir Ataturk State Hospital, Pediatric Endocrinology Unit, Balıkesir, Turkey.
28
Amerikan Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
29
Gaziosmanpaşa Taksim Training and Research Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
30
Edirne Sultan 1. Murat State Hospital, Pediatric Endocrinology Unit, Edirne, Turkey.
31
Medical Park Gaziosmanpasa Hospital, Pediatric Endocrinology Unit, Istanbul, Turkey.
32
University of Near East, Faculty of Medicine, Department of Pediatric Endocrinology, Nicosia, Turkish Republic of North Cyprus.
33
Istanbul University, Istanbul Faculty of Medicine, Department of Public Health, Istanbul, Turkey.

Abstract

OBJECTIVE:

To assess the incidence of type 1 diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015.

METHODS:

All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total as well as gender and age group specific (0-4, 5-9, 10-14 and 15-17 age) mean incidences per 100.000 per year were calculated.

RESULTS:

There were 1773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015). Of these, 862 (48.6%) were girls and 911(51.4%) were boys. The mean age at diagnosis was 9.2±4.2 years and it was not significantly different between girls (9.0±4.1 years) and boys (9.4±4.4 years) (p=0.052). The crude mean incidence was 8.99/100.000 (95% CI: 8.58-9.42). Although mean incidence was similar between boys [8.98/100.000 (CI:8.40 to 9.58)] and girls [9.01/100.000 (CI:8.42 to 9.63)], there was male predominance in all groups except for 5-9 year age group. The standardized mean incidence was 9.02/100.000 according to the World Health Organization standard population. The mean incidence for the 0-4, 5-9, 10-14 and 15-17 age groups was 6.13, 11.68, 11.7 and 5.04/100.000 respectively. The incidence of T1DM was similar over the course of 3 years (p=0.95). A significant increase in proportion of diagnosis of cases was observed in the autumn-winter seasons.

CONCLUSION:

Northwest region of Turkey is having an intermediate incidence of T1DM.

KEYWORDS:

Type 1 diabetes mellitus; childhood incidence.

PMID:
29789274
DOI:
10.4274/jcrpe.0025
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