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J Clin Res Pediatr Endocrinol. 2018 May 23. doi: 10.4274/jcrpe.0055. [Epub ahead of print]

Insulin Resistance is Related to Psychiatric Disorders Among Obese Children.

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Çiğli State Training Hospital, Department of Pediatrics, Division of Pediatric Endocrinology, İzmir, Turkey.
Manisa Celal Bayar University, School of Medicine, Department of Child and Adolescent Psychiatry, Manisa, Turkey.
Manisa Celal Bayar University, School of Medicine, Department of Pediatrics, Division of Pediatric İnfectious Disease, Manisa, Turkey.
Manisa Celal Bayar University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Manisa, Turkey.



The current study aimed to investigate psychiatric consequences of obesity (OBy) and the relationship between metabolic syndrome components and psychiatric disorders in children. Our secondaryaim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders.


The study included 88 obese(OB)and overweight (OW) children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by one child and adolescent psychiatrist. Forty patients who were diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. Body mass index (BMI), BMI-Standard deviation score (SDS) and BMI percentile, waist circumference (WC), waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serumglucose, insulin,lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured.


The presence of insulin resistance in group with psychiatric disorder was found significantly higher than in group without psychiatric disorder. Other anthropometric measurements and metabolic parameters were not significantly different between the two groups.


An understanding of the relationships between obesity related medical co-morbidities and psychiatric pathologies is important to encourage patients and their families for succesfull healthy lifestyle changes, weight management in terms of appropriate treatment.


Child; insulin resistance mental disorder.; obesity

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