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Elife. 2018 May 15;7. pii: e33505. doi: 10.7554/eLife.33505.

Preoptic leptin signaling modulates energy balance independent of body temperature regulation.

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Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States.
Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, United States.
Department of Physiology, School of Medicine, Tulane University, New Orleans, United States.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
The Warren Alpert Medical School, Department of Medicine, Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States.


The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis, and we have previously shown that glutamatergic, long-form leptin receptor (Lepr)-expressing neurons in the POA are stimulated by warm ambient temperature and suppress energy expenditure and food intake. Here we further investigate the role of POA leptin signaling in body weight regulation and its relationship to body temperature regulation in mice. We show that POA Lepr signaling modulates energy expenditure in response to internal energy state, and thus contributes to body weight homeostasis. However, POA leptin signaling is not involved in ambient temperature-dependent metabolic adaptations. Our study reveals a novel cell population through which leptin regulates body weight.


body weight; energy expenditure; food intake; high fat diet; knockdown; mouse; neuroscience; preoptic area

[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

SY, HC, MF, EQ, CH, YH, YJ, HG, YX, AZ, AD, EN, DB, CM, HB, HM No competing interests declared

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