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Neurobiol Aging. 2018 Aug;68:76-84. doi: 10.1016/j.neurobiolaging.2018.04.007. Epub 2018 Apr 17.

Predicted sequence of cortical tau and amyloid-β deposition in Alzheimer disease spectrum.

Author information

1
Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
2
Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea.
3
Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Division of RI-Convergence Research, Korea Institute Radiological and Medical Sciences, Seoul, South Korea.
4
Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
5
Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: lyoochel@yuhs.ac.

Abstract

We investigated sequential order between tau and amyloid-β (Aβ) deposition in Alzheimer disease spectrum using a conditional probability method. Two hundred twenty participants underwent 18F-flortaucipir and 18F-florbetaben positron emission tomography scans and neuropsychological tests. The presence of tau and Aβ in each region and impairment in each cognitive domain were determined by Z-score cutoffs. By comparing pairs of conditional probabilities, the sequential order of tau and Aβ deposition were determined. Probability for the presence of tau in the entorhinal cortex was higher than that of Aβ in all cortical regions, and in the medial temporal cortices, probability for the presence of tau was higher than that of Aβ. Conversely, in the remaining neocortex above the inferior temporal cortex, probability for the presence of Aβ was always higher than that of tau. Tau pathology in the entorhinal cortex may appear earlier than neocortical Aβ and may spread in the absence of Aβ within the neighboring medial temporal regions. However, Aβ may be required for massive tau deposition in the distant cortical areas.

KEYWORDS:

(18)F-flortaucipir; Alzheimer disease; Amyloid-β; PET; Tau

[Indexed for MEDLINE]

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