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Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4503-E4511. doi: 10.1073/pnas.1718099115. Epub 2018 Apr 23.

ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis.

Author information

1
Institute of Molecular, Cell and Systems Biology, University of Glasgow, G128QQ Glasgow, United Kingdom.
2
Glasgow Polyomics, University of Glasgow, G611QH Bearsden, United Kingdom.
3
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093.
4
Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
5
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037.
6
Institute of Molecular, Cell and Systems Biology, University of Glasgow, G128QQ Glasgow, United Kingdom; eirini.kaiserli@glasgow.ac.uk.

Abstract

Integration of environmental signals and interactions among photoreceptors and transcriptional regulators is key in shaping plant development. TANDEM ZINC-FINGER PLUS3 (TZP) is an integrator of light and photoperiodic signaling that promotes flowering in Arabidopsis thaliana Here we elucidate the molecular role of TZP as a positive regulator of hypocotyl elongation. We identify an interacting partner for TZP, the transcription factor ZINC-FINGER HOMEODOMAIN 10 (ZFHD10), and characterize its function in coregulating the expression of blue-light-dependent transcriptional regulators and growth-promoting genes. By employing a genome-wide approach, we reveal that ZFHD10 and TZP coassociate with promoter targets enriched in light-regulated elements. Furthermore, using a targeted approach, we show that ZFHD10 recruits TZP to the promoters of key coregulated genes. Our findings not only unveil the mechanism of TZP action in promoting hypocotyl elongation at the transcriptional level but also assign a function to an uncharacterized member of the ZFHD transcription factor family in promoting plant growth.

KEYWORDS:

Arabidopsis; development; light; transcription; zinc-finger

PMID:
29686058
PMCID:
PMC5948964
DOI:
10.1073/pnas.1718099115
[Indexed for MEDLINE]
Free PMC Article

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