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Obes Surg. 2018 Jul;28(7):2113-2116. doi: 10.1007/s11695-018-3249-1.

Liraglutide Effects on Upper Gastrointestinal Investigations: Implications Prior to Bariatric Surgery.

Author information

1
Department of Family Medicine, University of Alberta, Edmonton, AB, Canada. renuca@ualberta.ca.
2
Edmonton Adult Bariatric Specialty Clinic, Royal Alexandra Hospital, Edmonton, CSC 472, 10240 Kingsway Avenue, Edmonton, AB, T5H 3V9, Canada. renuca@ualberta.ca.
3
Richmond Road Diagnostic Treatment Centre, University of Calgary, Room 18126, 1820 Richmond Road SW, Calgary, AB, T2T 5C7, Canada.
4
Edmonton Adult Bariatric Specialty Clinic, Royal Alexandra Hospital, Edmonton, CSC 472, 10240 Kingsway Avenue, Edmonton, AB, T5H 3V9, Canada.
5
Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
6
Division of General Surgery, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Abstract

Liraglutide is a glucagon-like peptide type 1 (GLP-1) analogue that is approved for long-term obesity management in North America. While bariatric surgery remains the gold standard for weight loss, an increasing number of patients are on liraglutide in the setting of ongoing workup for bariatric surgery. The presence of gastrointestinal symptoms prior to bariatric surgery may prompt testing for dysmotility, which affects surgical decision making. Here we report six cases where treatment with liraglutide was associated with reversible reduction in gastric and esophageal motility in screening for bariatric surgery. While liraglutide is known to delay gastric emptying, there are minimal reports of how this medication affects gastrointestinal investigations used in this context. The implications of these abnormal screening investigations on candidacy for bariatric surgery are discussed.

KEYWORDS:

Bariatric surgery; Esophageal dysmotility; Gastroparesis; Liraglutide; Roux-en Y; Sleeve gastrectomy

PMID:
29667023
DOI:
10.1007/s11695-018-3249-1

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